Osmr oncostatin M receptor [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Osmrprovided by RGD
Official Full Name: oncostatin M receptorprovided by RGD
Primary source: RGD:1302983
See related: Ensembl:ENSRNOG00000033192 AllianceGenome:RGD:1302983
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including ciliary neurotrophic factor receptor binding activity; growth factor binding activity; and leukemia inhibitory factor receptor activity. Predicted to contribute to oncostatin-M receptor activity. Predicted to be involved in oncostatin-M-mediated signaling pathway and positive regulation of cell population proliferation. Predicted to be located in apical plasma membrane. Predicted to be part of oncostatin-M receptor complex. Predicted to be active in external side of plasma membrane. Human ortholog(s) of this gene implicated in primary localized cutaneous amyloidosis 1. Orthologous to human OSMR (oncostatin M receptor). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 70.5), Heart (RPKM 61.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q16

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (57634517..57688802, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (55907119..55961373, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (56107491..56163522, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

Osmr (e-PCR), detects polymorphism
- UniSTS:502730

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ciliary neurotrophic factor receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables cytokine binding	IBA Inferred from Biological aspect of Ancestor more info
enables cytokine binding	ISO Inferred from Sequence Orthology more info
enables cytokine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables growth factor binding	IEA Inferred from Electronic Annotation more info
enables growth factor binding	ISO Inferred from Sequence Orthology more info
contributes_to oncostatin-M receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables oncostatin-M receptor activity	IEA Inferred from Electronic Annotation more info
contributes_to oncostatin-M receptor activity	ISO Inferred from Sequence Orthology more info
enables oncostatin-M receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cytokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in oncostatin-M-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in oncostatin-M-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in response to cytokine	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
part_of oncostatin-M receptor complex	IEA Inferred from Electronic Annotation more info
part_of oncostatin-M receptor complex	ISO Inferred from Sequence Orthology more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: oncostatin-M-specific receptor subunit beta

Names: IL-31 receptor subunit beta; IL-31R subunit beta; IL-31R-beta; IL-31RB; interleukin-31 receptor subunit beta; oncostatin M specific receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001005384.2 → NP_001005384.2 oncostatin-M-specific receptor subunit beta precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002

UniProtKB/TrEMBL

F1LP92

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

57634517..57688802 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039102190.2 → XP_038958118.1 oncostatin-M-specific receptor subunit beta isoform X1

UniProtKB/Swiss-Prot

Q65Z14

UniProtKB/TrEMBL

F1LP92

Conserved Domains (4) summary

cd00063
Location:623 → 731

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam17971
Location:33 → 124

LIFR_D2; Leukemia inhibitory factor receptor D2 domain

pfam00041
Location:333 → 414

fn3; Fibronectin type III domain

cl21522
Location:539 → 605

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_039102195.2 → XP_038958123.1 oncostatin-M-specific receptor subunit beta isoform X2

UniProtKB/Swiss-Prot

Q65Z14

Conserved Domains (4) summary

cd00063
Location:622 → 730

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam17971
Location:33 → 124

LIFR_D2; Leukemia inhibitory factor receptor D2 domain

pfam00041
Location:333 → 414

fn3; Fibronectin type III domain

cl21522
Location:538 → 604

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_039102197.2 → XP_038958125.1 oncostatin-M-specific receptor subunit beta isoform X4

UniProtKB/Swiss-Prot

Q65Z14

Conserved Domains (3) summary

pfam17971
Location:33 → 124

LIFR_D2; Leukemia inhibitory factor receptor D2 domain

pfam00041
Location:333 → 414

fn3; Fibronectin type III domain

cl21522
Location:539 → 605

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_039102196.2 → XP_038958124.1 oncostatin-M-specific receptor subunit beta isoform X3

UniProtKB/Swiss-Prot

Q65Z14

Conserved Domains (3) summary

pfam17971
Location:33 → 124

LIFR_D2; Leukemia inhibitory factor receptor D2 domain

pfam00041
Location:333 → 414

fn3; Fibronectin type III domain

cl21522
Location:539 → 605

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_039102194.2 → XP_038958122.1 oncostatin-M-specific receptor subunit beta isoform X1

UniProtKB/Swiss-Prot

Q65Z14

UniProtKB/TrEMBL

F1LP92

Conserved Domains (4) summary

cd00063
Location:623 → 731

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam17971
Location:33 → 124

LIFR_D2; Leukemia inhibitory factor receptor D2 domain

pfam00041
Location:333 → 414

fn3; Fibronectin type III domain

cl21522
Location:539 → 605

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_039102192.2 → XP_038958120.1 oncostatin-M-specific receptor subunit beta isoform X1

UniProtKB/Swiss-Prot

Q65Z14

UniProtKB/TrEMBL

F1LP92

Conserved Domains (4) summary

cd00063
Location:623 → 731

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam17971
Location:33 → 124

LIFR_D2; Leukemia inhibitory factor receptor D2 domain

pfam00041
Location:333 → 414

fn3; Fibronectin type III domain

cl21522
Location:539 → 605

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_039102193.2 → XP_038958121.1 oncostatin-M-specific receptor subunit beta isoform X1

UniProtKB/Swiss-Prot

Q65Z14

UniProtKB/TrEMBL

F1LP92

Conserved Domains (4) summary

cd00063
Location:623 → 731

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam17971
Location:33 → 124

LIFR_D2; Leukemia inhibitory factor receptor D2 domain

pfam00041
Location:333 → 414

fn3; Fibronectin type III domain

cl21522
Location:539 → 605

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_039102191.2 → XP_038958119.1 oncostatin-M-specific receptor subunit beta isoform X1

UniProtKB/Swiss-Prot

Q65Z14

UniProtKB/TrEMBL

F1LP92

Related

ENSRNOP00000039644.3

Conserved Domains (4) summary

cd00063
Location:623 → 731

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam17971
Location:33 → 124

LIFR_D2; Leukemia inhibitory factor receptor D2 domain

pfam00041
Location:333 → 414

fn3; Fibronectin type III domain

cl21522
Location:539 → 605

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_039102198.2 → XP_038958126.1 oncostatin-M-specific receptor subunit beta isoform X5

UniProtKB/Swiss-Prot

Q65Z14

Conserved Domains (4) summary

cd00063
Location:623 → 731

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam17971
Location:33 → 124

LIFR_D2; Leukemia inhibitory factor receptor D2 domain

pfam00041
Location:333 → 414

fn3; Fibronectin type III domain

cl21522
Location:539 → 605

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...